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Lumifer comments on Stupid questions thread, October 2015 - Less Wrong
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Whatever actually works on your headaches. Humans are different.
As far as I can tell, they all work. Are any of these more hazardous to long-term health than others?
If you take them often enough you should research this, but off the top of my head acetaminophen (Tylenol) damages your liver while aspirin is recommended to the elderly as a long-term "maintenance" drug to reduce cardiovascular problems. On the other hand, it's an overdose of acetaminophen that kills your liver, while aspirin can cause things like internal bleeding.
As usual, you pick from a menu of risks and you choose what's best for your particular situation.