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gwern comments on Open Thread, January 4-10, 2016 - Less Wrong
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People in the studies presumably don't take it all in the morning. Do you have an estimate of how that affects the total effect? How much bigger would you estimate the effect to be when people take it in the morning?
I take it in the morning just because I found that taking it late at night harmed my sleep. I have no idea how much people taking it later in the day might reduce benefits by damaging sleep; I would guess that the elderly people usually enrolled in these trials would be taking it as part of their breakfast regimen of pills/prescriptions and so the underestimate of benefits is not that serious.