RyanCarey comments on A Medical Mystery: Thyroid Hormones, Chronic Fatigue and Fibromyalgia - Less Wrong
You are viewing a comment permalink. View the original post to see all comments and the full post content.
You are viewing a comment permalink. View the original post to see all comments and the full post content.
Comments (159)
Ryan, thank you again. Your concerns are my concerns, I am grateful to you for them.
And I apologise. You have been talking to a raving lunatic, by the ICD10 diagnostic criteria as applied by my attorney and myself. See the exchange with buybuydandavis for details. I am apparently recovered now, in the opinion of one who should know.
I am painfully aware that I have reasoned myself into a place where I prove too much.
I am in the position of a philosopher who started out with a little detail, and is now claiming 'It is at least marginally possible that here is the light and the sacred cup'. Knowing that he is wrong.
I was carefully and expensively trained to speak with certainty when and only when I was certain. The Lord knows I was never very good at it.
I have used plausible reasoning where I only trust classical logic.
I am forced to seek the Grail.
But I cannot shake the suspicion that I might be right. And I know that my hopeless hardware will not let me find the reason why I am wrong.
It has. The germ theory.
I am claiming that the great killers of the past may have left their shadows in our genes, and those shadows still plague us today.
I am claiming that the great changes we have made in our environment may have hurt us worse than we know.
Here I stand, naked to the world. Afraid. I can do no other in good conscience. I do not believe my own conclusion.
I hope that when I am shown to be wrong, I can retreat with no more than huge embarrassment, resolving to fail better next time.
And it all depends on the TSH test. If I am wrong about that, I am just wrong.
If the TSH test is flawed, then all our statistics are confounded, and we have some thinking to do.
Still Crocker's Rules though! Let this cup pass from me!
Forget about being proved wrong and facing huge embarassment.
Short-circuit that by getting some background domain knowledge then making claims that in light of that knowledge are reasonable.
OK, type 2 diabetics, suffering from a mysterious condition that prevents insulin (an endocrine hormone) acting on their cells, can achieve very good blood sugar control by overwhelming the resistance with exogenous insulin.
And yet they still suffer horrible complications. Which look awfully like hypothyroidism.
The simplest explanation is that this mysterious condition is interfering with other endocrine hormones as well.
Desiccated thyroid, containing excessive T3, will overwhelm the hormone resistance, and clear up the complications of diabetes.
T4 alone will not change the amount of T3 in the blood significantly, since it is subject to the body's T4->T3 conversion mechanism, which defends T3 levels.
Therefore T4 will not help diabetics, but T4/T3 combinations will.
Broda Barnes observed this empirically in the sixties. I predicted it independently before I read his book.
Find a diabetic colleague, and explain this to him. I predict that he will suddenly take the idea very seriously indeed.