Sometime ago I figured out a refutation of this kind of reasoning in Counterfactual Mugging, and it seems to apply in Newcomb's Problem too. It goes as follows:

Imagine another god, Upsilon, that offers you a similar two-box setup - except to get the $2M in the box B, you must be a one-boxer with regard to Upsilon and a two-boxer with regard to Omega. (Upsilon predicts your counterfactual behavior if you'd met Omega instead.) Now you must choose your dispositions wisely because you can't win money from both gods. The right disposition depends on your priors for encountering Omega or Upsilon, which is a "bead jar guess" because both gods are very improbable. In other words, to win in such problems, you can't just look at each problem individually as it arises - you need to have the correct prior/predisposition over all possible predictors of your actions, before you actually meet any of them. Obtaining such a prior is difficult, so I don't really know what I'm predisposed to do in Newcomb's Problem if I'm faced with it someday.