kamenin comments on Newcomb's Problem and Regret of Rationality - Less Wrong
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I have two arguments for going for Box B. First, for a scientist it's not unusual that every rational argument (=theory) predicts that only two-boxing makes sense. Still, if the experiment again and again refutes that, it's obviously the theory that's wrong and there's obviously something more to reality than that which fueled the theories. Actually, we even see dilemmas like Newcomb's in the contextuality of quantum measurements. Measurement tops rationality or theory, every time. That's why science is successful and philosophy is not.
Second, there's no question I choose box B. Either I get the million $ -- or I have proven an extragalactical superintelligence wrong. How cool is that? 1000$? Have you looked at the exchange rates lately?