So Scott Alexander's post at http://slatestarcodex.com/2016/03/01/2016-nootropics-survey-results/ shows that the most "effective" "nootropics" have still been the ones that have existed for a long time. What do these results really mean, though? Is it possible that people are just worse at noticing the subtler effects of the other drugs, or are just much worse at disciplining themselves enough to correctly use the racetams or noopept (as in, with choline)?
How much potential is there in innovation in nootropics? What is holding this innovation back, if anything? It feels like there hasn't been any real progress over the last 15 years (other than massively increased awareness), but could targeted drug discovery (along with people willing to be super-liberal with their experimentation) finally lead to some real breakthroughs?
Probably because of different genes, which are thousands, and different early development wiring and education. It can't be replaced by a few drugs.
Miller's point being that those thousands of genes can easily be driven to fixation by evolution within a fairly short time, yet have not, and it's not clear from the GWASes yet if they're even under directional selection.
Right now, between the GCTAs and the failure to find lots of important rare variants affecting intelligence such as mutation load (eg no Swedish paternal age effect, unlike many disorders), the consensus seems to be swinging towards some sort of frequency-dependent or stabilizing selection: greater intelligence comes with some sort of fi... (read more)