MarsColony_in10years comments on What is the future of nootropic drugs? Why can't there be ones more effective than ones that have existed for 15+ years? - Less Wrong
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I believe CronoDAS is referring to Algernon's Law. Gwern describes the issues pretty well here, including several classes on "loopholes" we might employ to escape the general rule.
The classifications of different types of loopholes is still pretty high level, and I'd love to see some more concrete and actionable proposals. So, don't take this as saying "this is old hat", but only as a jumping off point for further discussion.