Douglas_Knight comments on What is the future of nootropic drugs? Why can't there be ones more effective than ones that have existed for 15+ years? - Less Wrong
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We know that the variation in any single locus is responsible for < 1/100 of the variance of IQ. If genes corresponded to drugs, then that gives an upper bound on the efficacy of drugs. I think that we can agree that 100 does not counts as "a few."