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johnlawrenceaspden comments on The Thyroid Madness: Two Apparently Contradictory Studies. Proof? - Less Wrong
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10 mg was what showed thyroid enlargement, but they saw hormone changes without definitive toxicological effects at all doses down to the minimum they tried, ten micrograms per kg per day. Quote:
"Statistically significant changes in TSH and thyroid hormones were observed at all AP dosage levels tested; however, no thyroid organ weight or histopathological effects were observed at AP dosage levels < or = 1.0 mg/kg/day. In the absence of thyroid organ weight and histopathological effects, the toxicological significance of TSH and thyroid hormone changes at AP dosage levels < or = 1.0 mg/kg/day remains to be determined."
I have little strong opinion here, just noting that they saw subtle hormone changes at very low doses and it's hard to ask a mouse how they feel.
This is absolutely evidence that huge doses of this stuff knacker your thyroid. But huge doses of most nasty chemicals probably do that. There's no particular reason to finger this as a significant cause unless it's in the environment in huge doses.