johnlawrenceaspden comments on The Thyroid Madness: Two Apparently Contradictory Studies. Proof? - Less Wrong
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Isn't it still "its day"?
Think of it this way. There is a set of people with some clinical symptoms which look maybe-possibly like hypothyroidism. There is a another set of people with abnormal TSH. These sets partially intersect and form three subsets. Subset one is the intersection: people with both clinical symptoms and abnormal TSH. They are a clear case and there are no problems here. Subset two is abnormal TSH and absence of clinical symptoms. We interpret that as thyroid gland falling apart and expect clinical symptoms to appear in the near future. We are not concerned with people either.
Subset three is the one you are interested in: people with normal TSH and clinical symptoms. What about them? Well, as you mention diagnosing hypothyroidism solely on the basis of clinical symptoms is difficult. So in this subset some but not all people will have a thyroid malfunction, and some will have other problems, maybe instead or maybe in addition to thyroid issues.
By the way, the people who you insist on calling "fat, tired, and with dry skin" are in subset three. They exhibit clinical symptoms of hypothyroidism.
Your suggestion is that we give some dessicated thyroid to subset three and see if it helps. Well, it's pretty clear that it will help some people and will not help other people (for example, those fat and tired ones). However that is true of many medical interventions.
For example, there are probably males in subset three with low testosterone. So giving testosterone to subset three males will also help some people and not help others. There also probably people with low-grade systemic infections in there. Giving broad-spectrum antibiotics to subset three might well help some people and not help others. There are likely people with autoimmune disorders there...
Basically, if you have little idea about what's wrong, trying a variety of drugs hoping for a lucky hit is not necessarily a horrible strategy (depends on the side-effects of the drugs and the consequences of doing nothing), but it's not much advancement from the good old times.
Let me quote from West Hunter:
P.S. Note the awe-inspiring lack of smugness with which I present:
IMPAIRED ACTION OF THYROID HORMONE ASSOCIATED WITH SMOKING IN WOMEN WITH HYPOTHYROIDISM
BEAT MÜLLER , M.D., HENRYK ZULEWSKI , M.D., PETER HUBER , P H .D., JOHN G. RATCLIFFE , M.D., AND JEAN -JACQUES STAUB , M.D.
I bloody said it would turn out to be the reason smoking's bad for you, didn't I? And at the same time it's evidence that acquired hormone resistance exists, and this one fingers an environmental cause.