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I think that if we include all driving habits, single car crashes, observation selection we will get probably 1 in 10 difference, but I still surprised by 1 to 1000 difference in fatalities between most dangerous and most safe cars.
I think that also weight is very important factor: heavier cars are much safer.
Heavier cars are safer for the people in the heavier cars, and more dangerous for others with whom they may collide.
This produces a sort of evolutionary arms race in the direction of larger heavier cars, making everyone less safe overall.
(Other changes in car design have made them much safer over the years. Today's cars are much safer than those of, say, 30 years ago. But not, I think, because they are heavier.)