You would, at the very least, be in violation of several acts regarding approval of GMOs: https://www.loc.gov/law/help/restrictions-on-gmos/usa.php https://en.wikipedia.org/wiki/Regulation_of_the_release_of_genetically_modified_organisms#United_States Specifically, you'd be violating FDA requirements by releasing '“new animal drugs” (NADs)' without approval. Depending on whether mosquitoes are considered plant pests, it looks like you'd also be violating Department of Agriculture laws. I assume you'd probably also be violating a number of EPA laws but didn't see anything specifically about that.