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Good_Burning_Plastic comments on Now is the time to eliminate mosquitoes - Less Wrong
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Killing all mosquitoes would be way too likely to have seriously bad unintended consequences IMO.
It would be something that I'd like to ask an expert about, but I think it's worth considering.
More generally: the ecosystem we have today is almost certainly not the best one we could possibly have. Therefore there may be feasible positive changes we can make to it.
Define "best".