Reductionism is great. The main problem is that by itself it tells us nothing new. Science depends on hypothesis generation, and reductionism says nothing about how to do that in a rational way, only how to test hypotheses rationally. For some reason the creative side of science -- and I use the word "creative" in the generative sense -- is never addressed by methodology in the same way falsifiability is:

http://emergentfool.com/2010/02/26/why-falsifiability-is-insufficient-for-scientific-reasoning/

We are at a stage of historical enlightenment where more and better reductionism is producing marginal returns. To be even less wrong, we might spend more time on the hypothesis generation side of the equation.