This may be the rare case where I'm more of a materialist reductionist than you, Eliezer. I think unhappiness is just brain structure/chemistry. I'd go further than Ferris and say excitement is too. The flip side of this is that you may be giving a lot of people bad advice and unrealistic expectations in this post. For a lot of people their unhappiness is a complicated unsolved challenge of bioengineering. With better technology, perhaps we'll be able to solve it. Until then, they may spend a period of time being unhappy, not due to the fuzzy advice you give in the last paragraph. And not due to anything about "morality".