"Now, if someone is in a unproblematic, loving relationship; and they have enough money; and no major health problems; and they're signed up for cryonics so death is not approaching inexorably; and they're doing exciting work that they enjoy; and they believe they're having a positive effect on the world...

...and they're still unhappy because it seems to them that the universe is a mere dance of atoms empty of meaning, then we may have a legitimate problem here. One that, perhaps, can only be resolved by a very long discussion of the nature of morality and how it fits into a reductionist universe"

Apart from the cryonics thing (thinking about it), I fit into this category. But I am not holding my breath that you are going to provide any plausible arguments. It would be good if you actually engaged with the literature about this as well, as well as doing your own thing the WHOLE time.