Re: Wireheading - and a short-term increase in pleasure happiness at the cost of a long-term decrease in average pleasure.

Heroin looks good to me - or at least is the best we have - unless a specific medical condition is making you sadder than normal.

You cannot reasonably expect to become a wirehead without your life going up the tubes - resulting in massive stimulation of your pain and unhappiness circuitry - but, by most accounts, heroin remains pretty effective at making all that go away - at least up until near the end. Behaviourally, a heroin addict is effectively indistinguishable from a wirehead.

As Renton said: "Take the best orgasm you ever had, multiply it by a thousand and you're still nowhere near it."