"And I wonder if that advice will turn out not to help most people, until they've personally blown off their own foot, saying to themselves all the while, correctly, "Clearly I'm winning this argument.""

I fell into this pattern for quite a while. My basic conception was that, if everyone presented their ideas and argued about them, the best ideas would win. Hence, arguing was beneficial for both me and the people on transhumanist forums- we both threw out mistaken ideas and accepted correct ones. Eliezer_2006 even seemed to support my position, with Virtue #5. It never really occurred to me that the best of everyone's ideas might not be good enough.

"It is Nature that I am facing off against, who does not match Her problems to your skill, who is not obliged to offer you a fair chance to win in return for a diligent effort, who does not care if you are the best who ever lived, if you are not good enough."

Perhaps we should create an online database of open problems, if one doesn't exist already. There are several precedents (http://en.wikipedia.org/wiki/Hilbert%27s_problems). So far as I know, if one wishes to attack open problems in physics/chemistry/biology/comp. sci./FAI, the main courses of action are to attack famous problems (where you're expected to fail and don't feel bad if you do), or to read the educational literature (where the level of problems is pre-matched to the level of the material).