jsalvati comments on The Sheer Folly of Callow Youth - Less Wrong
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"you cannot come up with clever reasons why the gaps in your model don't matter." Sure, sometimes you can't, but sometimes you can; sometimes there are things which seem relevant but which are genuinely irrelevant, and you can proceed without understanding them. I don't think it's always obvious which is which, but of course, it's a good idea to worry about falsely putting a non-ignorable concept into the "ignorable" box.