I might add, for the benefit of others, that self-sampling forbids playing favourites among which observers to believe that you are in a single universe (beyond what is actually justified by the evidence available), and self-indication forbids the same across possible universes.
Nominull: It's a bad habit of some people to say that reality depends on, or is relative to observers in some way. But even though observers are not a special part of reality, we are observers and the data about the universe that we have is the experience of observers, not an outside view of the universe. So long as each universe has no more than one observer with your experience, you can take your experience as objective evidence that you live in a universe with one such observer instead of zero (and with this evidence to work with, you don't need to talk about observers). But it's difficult to avoid talking about observers when a universe might have multiple observers with the same subjective experience.
Recently the Large Hadron Collider was damaged by a mechanical failure. This requires the collider to be warmed up, repaired, and then cooled down again, so we're looking at a two-month delay.
Inevitably, many commenters said, "Anthropic principle! If the LHC had worked, it would have produced a black hole or strangelet or vacuum failure, and we wouldn't be here!"
This remark may be somewhat premature, since I don't think we're yet at the point in time when the LHC would have started producing collisions if not for this malfunction. However, a few weeks(?) from now, the "Anthropic!" hypothesis will start to make sense, assuming it can make sense at all. (Does this mean we can foresee executing a future probability update, but can't go ahead and update now?)
As you know, I don't spend much time worrying about the Large Hadron Collider when I've got much larger existential-risk-fish to fry. However, there's an exercise in probability theory (which I first picked up from E.T. Jaynes) along the lines of, "How many times does a coin have to come up heads before you believe the coin is fixed?" This tells you how low your prior probability is for the hypothesis. If a coin comes up heads only twice, that's definitely not a good reason to believe it's fixed, unless you already suspected from the beginning. But if it comes up heads 100 times, it's taking you too long to notice.
So - taking into account the previous cancellation of the Superconducting Supercollider (SSC) - how many times does the LHC have to fail before you'll start considering an anthropic explanation? 10? 20? 50?
After observing empirically that the LHC had failed 100 times in a row, would you endorse a policy of keeping the LHC powered up, but trying to fire it again only in the event of, say, nuclear terrorism or a global economic crash?