You don't think humanity would ever willingly go for destructive uploading?

Understand my meaning, do not cleave my words. I mean of course "six billion mind-state annihilations," and I highly doubt you were not able to think of that interprentation.

I don't think win/lose is too useful here. The idea that there are many ways to lose is like saying that most arrangements of a 747's components don't fly. True - but not too relevant when planning a flight.

But there are any number of failure points and combinations thereof that would be mission-fatal during flight.