Chrysophylax comments on Serious Stories - Less Wrong
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On the other hand, there must be some downside to pain asymbolia, or we'd all have it. (Plainly the mutation exists; why isn't it selected for?)
Because a child who doesn't find pain unpleasant is really, really handicapped, even in the modern world. The people who founded A Gift of Pain had a daughter with pain asymbolia who is now mostly blind, amongst other disabilities, through self-inflicted damage. I'm not sure whether leprosy sufferers have the no-pain or no-suffering version of pain insensitivity (I think the former) but apparently it's the reason they suffer such damage.
This book seems to be a useful source for people considering the question of whether pain could be improved.