Unfortunately, it seems to me that moral anti-realism and axiological anti-realism place limits on our ability to "optimize" the universe.
To put the argument in simple terms:
Axiological/Moral anti-realism states that there are no categorically good states of the universe. On this we agree. The goodness of states of the universe is contingent upon the desires and values of those who ask the question; in this case us.
Human minds can only store a finite amount of information in our preferences. Humans who have spent more time developing their character beyond the evolutionarily programmed desires [food, sex, friendship, etc] will fare slightly better than those who haven't, i.e. their preferences will be more complicated. But probably not by very much, information theoretically speaking. The amount of information your preferences can absorb by reading books, by having life experiences, etc is probably small compared to the information implicit in just being human.
The size of the mutually agreed preferences of any group of humans will typically be smaller than the preferences of any one human. Hence it is not surprising that in the recent article on "Failed Utopia 4-2" there was a lot of disagreement regarding the goodness of this world.
The world that we currently live in here in the US/UK/EU fails to fulfill a lot of the base preferences that are common to all humans, with notable examples being the dissatisfaction with the opposite sex, boring jobs, depression, aging, etc, etc...
If one optimized over these unfulfilled preferences, one would get something that resembled - for most people - a low grade utopia that looked approximately like Banks' Culture. This low grade utopia would probably only be a small amount of information away from the world we see today. Not that it isn't worth doing, of course!
This explains a lot of things. For example, the change of name of the WTA from "transhumanist" to "humanity plus". Humanity plus is code for "low grade utopia for all". "Transhumanist" is code for futures that various oddball individuals envisage in which they (somehow) optimize themselves way beyond the usual human preference set. These two futures are eminently compatible - we can have them both, but most people show no interest in the second set of possibilities. It will be interesting to think about the continuum between these two goals. It's also interesting to wonder whether the goals of "radical" transhumanists might be a little self-contradictory. With a limited human brain, you can (as a matter of physical fact) only entertain thoughts that constrain the future to a limited degree. Even with all technological obstacles out of the way, our imaginations might place a hard limit on how good a future we can try to build for ourselves. Anyone who tries to exceed this limit will end up (somehow) absorbing noise from their environment and incorporating it into their preferences. Not that I have anything against this - it is how we got our preferences in the first place - though it is not a strong motivator for me to fantasize about spending eternity fulfilling preferences that I don't have yet and which I will generate at random at some point in the future when I realize that my extant preferences have "run out of juice".
This, I fear, is a serious torpedo in the side of the transhumanist ideal. I eagerly await somebody proving me wrong here...
(A shorter gloss of Fun Theory is "31 Laws of Fun", which summarizes the advice of Fun Theory to would-be Eutopian authors and futurists.)
Fun Theory is the field of knowledge that deals in questions such as "How much fun is there in the universe?", "Will we ever run out of fun?", "Are we having fun yet?" and "Could we be having more fun?"
Many critics (including George Orwell) have commented on the inability of authors to imagine Utopias where anyone would actually want to live. If no one can imagine a Future where anyone would want to live, that may drain off motivation to work on the project. The prospect of endless boredom is routinely fielded by conservatives as a knockdown argument against research on lifespan extension, against cryonics, against all transhumanism, and occasionally against the entire Enlightenment ideal of a better future.
Fun Theory is also the fully general reply to religious theodicy (attempts to justify why God permits evil). Our present world has flaws even from the standpoint of such eudaimonic considerations as freedom, personal responsibility, and self-reliance. Fun Theory tries to describe the dimensions along which a benevolently designed world can and should be optimized, and our present world is clearly not the result of such optimization. Fun Theory also highlights the flaws of any particular religion's perfect afterlife - you wouldn't want to go to their Heaven.
Finally, going into the details of Fun Theory helps you see that eudaimonia is complicated - that there are many properties which contribute to a life worth living. Which helps you appreciate just how worthless a galaxy would end up looking (with very high probability) if the galaxy was optimized by something with a utility function rolled up at random. This is part of the Complexity of Value Thesis and supplies motivation to create AIs with precisely chosen goal systems (Friendly AI).
Fun Theory is built on top of the naturalistic metaethics summarized in Joy in the Merely Good; as such, its arguments ground in "On reflection, don't you think this is what you would actually want for yourself and others?"
Posts in the Fun Theory sequence (reorganized by topic, not necessarily in the original chronological order):