Out of curiosity, what would you be inclined to say about a random woman who simply did not know any men and who socialized exclusively with women, none of whom knew any men either?

The mind boggles at such a concept. However, you probably mean a woman who did not know any men she considered potential partners, and who socialized with women, none of whom knew any men they considered introducing as potential partners... in which case, that sounds like a lot of women. ;-)

So, I'm not entirely sure where you meant to draw the line, there. But unless you were trying to imply that she's a nun or a lesbian, though, you need to understand that men (in general, though not always in every specific case) simply wouldn't care.

Likely male responses to this condition in reality would be things like, "Cool, a virgin", or "Great, she won't have anybody to compare me to", or "wow, so many women not knowing guys... think of the opportunities for me!"

In fact, my first joking response that I almost typed at the beginning of this comment was that I'd say, "Welcome to Fantasy Island!" -- because that's more or less the evolutionary-instinctual male response to the idea of "lots of women without any men around", i.e. "awesome".

IOW, the female preference for men to have social connections just doesn't translate in reverse. Men have different evolutionary drives in this respect, which is why guys who think just enough about this stuff to notice it (but not enough to properly translate/balance) tend to end up with all sorts of grudges against women's preferences as being "irrational" and "unfair" (i.e. not-the-same-as-men's).