You're given the option to torture everyone in the universe, or inflict a dust speck on everyone in the universe. Either you are the only one in the universe, or there are 3^^^3 perfect copies of you (far enough apart that you will never meet.) In the latter case, all copies of you are chosen, and all make the same choice. (Edit: if they choose specks, each person gets one dust speck. This was not meant to be ambiguous.)
As it happens, a perfect and truthful predictor has declared that you will choose torture iff you are alone.
What do you do?
How does your answer change if the predictor made the copies of you conditional on their prediction?
How does your answer change if, in addition to that, you're told you are the original?
Either you misunderstand the smoking lesions scenario and the importance between the difference between a correlation and a perfect predictor, or you're just trolling the board by throwing every decision theory edge case you can think of into a single convoluted mess.
I may be misunderstanding something, but isn't the standard LW position on smoking to smoke even if the gene's correlation to smoking and cancer is 1?
As long as the predictor doesn't cause anything but merely informs, they're equivalent to the gene. The reason why one-boxing is correct is because your choice causes the money, while the reason smoking is correct is because your choice doesn't cause cancer.