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Certainly that is an important point to consider. I could always place funds in a donor advised fund for now. However, if an organization that I donated to thought the funds would be best spent later, they could invest the funds. Considering this, my current thinking is that I should donate to an organization if they share the goal of reducing existential risk and I think they would be better at deciding on the best course of action than I would. Considering I am not currently an expert in areas which would prove useful to reducing existential risk, I'm leaning towards donating. Does this seem like a sensible course of action?
In practice, charities don't really invest excess money or take out loans to spend money sooner. I'm not sure why. Possible explanations: