While the argument was posted on LessWrong previously, now it has the neat form of a paper on arXive by Anders Sandberg, Eric Drexler and Toby Ord
TL;DR version: the use of Drake-like equations, with point estimates of highly uncertain parameters, is wrong. Extant scientific knowledge corresponds to uncertainties that span multiple orders of magnitude.
When the statistics is done correctly to represent realistic distributions of uncertainty in the literature, "people who take the views of most members of the research community seriously should ascribe something like a one in three chance to being alone in the galaxy and so should not be greatly surprised by our lack of evidence of other civilizations. The probability of N <10^−10 (such that we are alone in the observable universe) is 10%. "
From the conclusions, when the priors are updated
When we update this prior in light of the Fermi observation, we find a substantial probability that we are alone in our galaxy, and perhaps even in our observable universe (53%–99.6% and 39%–85% respectively). ’
What do you mean by "real point"? Don't you mean that the point of the paper is that someone makes a particular mistake?
I mean the mistake of computing expected number rather than probability. I guess the people in the 60s, like Drake and Sagan probably qualify. They computed an expected number of planets, because that's what they were interested in, but were confused because they mixed it up with probability. But after Hart (1975) emphasizes the possibility that there is no life out there, people ask the right question. Most of them say things like "Maybe I was wrong about the probability of life." That's not the same as doing a full bayesian update, but surely it counts as not making this mistake.
It's true that Patrick asserts this mistake. And maybe the people making vague statements of the form "maybe I was wrong" are confused, but not confused enough to make qualitatively wrong inferences.