Open problems are clearly defined problems1 that have not been solved. In older fields, such as Mathematics, the list is rather intimidating. Rationality, on the other, seems to have no list.
While we have all of us here together to crunch on problems, let's shoot higher than trying to think of solutions and then finding problems that match the solution. What things are unsolved questions? Is it reasonable to assume those questions have concrete, absolute answers?
The catch is that these problems cannot be inherently fuzzy problems. "How do I become less wrong?" is not a problem that can be clearly defined. As such, it does not have a concrete, absolute answer. Does Rationality have a set of problems that can be clearly defined? If not, how do we work toward getting our problems clearly defined?
See also: Open problems at LW:Wiki
1: "Clearly defined" essentially means a formal, unambiguous definition. "Solving" such a problem would constitute a formal proof.
Well, I can give some classes of problems. For instance, many of the biases that we know about, we don't really know good ways for humans to reliably correct for. So right there is a whole bunch of open problems. (I know of some specific ones with known debiasing techniques, but many are "okay, great, I know I make this error... but other than occasionally being lucky enough to directly catch myself in the act of doing so, it's not really obvious how to correct for these")
Another, I guess vaguer one would be "general solution that allows people to solve their akrasia problems"