Open problems are clearly defined problems1 that have not been solved. In older fields, such as Mathematics, the list is rather intimidating. Rationality, on the other, seems to have no list.
While we have all of us here together to crunch on problems, let's shoot higher than trying to think of solutions and then finding problems that match the solution. What things are unsolved questions? Is it reasonable to assume those questions have concrete, absolute answers?
The catch is that these problems cannot be inherently fuzzy problems. "How do I become less wrong?" is not a problem that can be clearly defined. As such, it does not have a concrete, absolute answer. Does Rationality have a set of problems that can be clearly defined? If not, how do we work toward getting our problems clearly defined?
See also: Open problems at LW:Wiki
1: "Clearly defined" essentially means a formal, unambiguous definition. "Solving" such a problem would constitute a formal proof.
This is not a game question, but it may be an interesting question regarding decision making for humans:
What is the total Shannon entropy of the variables controlling whether or not a human will do what it consciously believes will lead to the most desirable outcome?
If all humans currently alive collectively represent every possible variable combination in this regard, the maximum value for the answer is 32.7 bits[1]. That is, 33 on/off switches completely decide whether or not you will put off doing your homework[2]. Is the correct value higher or lower?
Some variables might be aggregated from analog sources, such as adrenaline level, in combination with a series of thresholds specific to the individual.
I made up this question just now, and suspect it may be insanely stupid.
Much, much higher. The humans currently alive represent only a very sparse sampling of possible combinations of genes, and an even sparser sampling of possible combinations of life experiences. I don't see any obvious reason why the answer to this question shouldn't be greater than the number of subatomic particles in your body.