Sam Harris is here offering a substantial amount of money to anyone who can show a flaw in the philosophy of 'The Moral Landscape' in 1000 word or less, or at least the best attempt.
http://www.samharris.org/blog/item/the-moral-landscape-challenge1
Up to $20,000 is on offer, although that's only if you change his mind. Whilst we know that this is very difficult, note how few people offer large sums of money for the privelage of being disproven.
In case anyone does win, I will remind you that this site is created and maintained by people who work at MIRI and CFAR, which rely on outside donations, and with whom I am not affiliated.
Note: Is this misplaced in Discussion? I imagine that it could be easily overlooked in an open thread by the sorts of people who would be able to use this information well?
You can't go from an is to an ought. Nevertheless, some people go from the "well-being and suffering" idea to ideas like consequentialism and utilitarianism, and from there the only remaining questions are factual. Other people are prepared to see a factual basis for morality in neuroscience and game theory. These are regular topics of discussion on LW. So calling it "obvious" begs the whole question.