The Big Bang Theory, Episode 402.

Sheldon (the most socially atypical character on a show full of them) plans a program of life-extension so that he will last until the Singularity, which he projects to occur around 2060 and chiefly involve the uploading of human consciousness into machines (his roommate Leonard describes the latter as become a "freakish self-aware robot". By the end of the episode Sheldon seems to have given up on the plan as too inconvenient/inadvertently dangerous.