Transexuals pick their gender based on their feelings, and they fully have a right to do that in my opinion. But lets say that currently the costs for that kind of change are too high for most people and pick a different example:

How in the world will I get any work done with a commie in the office? How in the world will I get any work done with a atheist in the office? How in the world will I get any work done with a eugenicist in the office? How in the world will I get any work done with a republican in the office? How in the world will I get any work done with a Jew in the office? ect.