I've played that :) It's cool & does have a chilling effect. If I still thought nuclear war was the most terrible thing likely to happen (oh, such innocent times) if would probably have affected me lots.
So what's the common theme? Looks like we need eerie background music, low budget, basic/retro graphics, end of the world theme, player responsible for billions of deaths... :-o
PS. Roger Ebert is prepared to believe that "video games can be elegant, subtle, sophisticated, challenging, and visually wonderful". I think he should taboo "art".
http://www.newgrounds.com/portal/view/555181
It needn't take more than 10 minutes to play, though it might if you nail-bite about your choices. I'm curious about the LW response, although I might be underwhelmed by lack of interest.