All the way back in chapter 1, Petunia says:
And Lily would tell me no, and make up the most ridiculous excuses, like the world would end if she were nice to her sister, or a centaur told her not to - the most ridiculous things, and I hated her for it.
The main (although not the only difference) between canon and HPMR is Lily and Petunia's interaction in this context. In canon, centaurs are creatures which see the future. This makes me very worried that a centaur foresaw that if Lily helped Petunia bad things would result. Since this is the main departure from canon, is this a reason to think that the story is going to have a really downer ending?
To comply with the prophesy, her actions need only result in a bad ending for centaurs.
Update: Discussion has moved on to a new thread.
The load more comments links are getting annoying (at least if you're not logged in), so it's time for a new Harry Potter and the Methods of Rationality discussion thread. We're also approaching the traditional 500-comment mark, but I think that hidden comments provide more appropriate joints to carve these threads at. So as of chapter 67, this is the place to share your thoughts about Eliezer Yudkowsky's Harry Potter fanfic.
The first 5 discussion threads are on the main page under the harry_potter tag. Threads 6 and on (including this one) are in the discussion section using its separate tag system. Also: one, two, three, four, five, six. The fanfiction.net author page is the central author-controlled HPMOR clearinghouse with links to the RSS feed, pdf version, TV Tropes pages, fan art, and more, and AdeleneDawner has kept an archive of Author's Notes.
As a reminder, it's often useful to start your comment by indicating which chapter you are commenting on.
Spoiler Warning: this thread is full of spoilers. With few exceptions, spoilers for MOR and canon are fair game to post, without warning or rot13. More specifically: