inblankets comments on A rationalist's guide to psychoactive drugs - Less Wrong Discussion
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I don't know about other cities, but I've used heroin in NYC off and on for almost 5 years, and I can safely say that, although I attempted to control for nutrition etc., I almost always had some deleterious effects on my skin etc. from (presumably) additives, even using "pure" stuff. If you're taking something in intravenously, very pure is not pure enough.