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gwern comments on Eight questions for computationalists - Less Wrong Discussion
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Maybe not with humans, but definitely for octopuses!
(More seriously, depending on how seriously you take embodied cognition, there may be some small loss. I mean, we know that your gut bacteria influence your mood via the nerves to the gut; so there are connections. And once there are connections, it becomes much more plausible that cut connections may decrease consciousness. After a few weeks in a float tank, how conscious would you be? Not very...)
I'm pretty sure that you agree that none of this means that a human brain in a vat with proper connections to the environment, real or simulated, is inherently less conscious than one attached to a body.
I don't take embodiment that far, no, but a simulated amputation in a simulation would seem as problematic as a real amputation in the real-world barring extraordinary intervention on the part of the simulation.