Agree with all of the above. Also, drop-down menus frustrate me when I misaim a mouse click, frustrate me when using a very slow computer, frustate me when Javascript is off, and are generally the spawn of Satan.
On the plus side: whee, it looks pretty and light and stuff! (The thick borders are ugly - maybe keep lime for new comments but don't change border width.) Turning karma bubbles to karma bricks was a good idea. The header and footer are good (though the two icons are too dark for many screen configurations). The "nearby meetups" section is a really, really good idea. Yay.
I saw some discussion posts earlier talking about a LessWrong redesign, and now that things look different, I guess that it's been implemented. I'm always slightly annoyed for a while when a site I use gets redesigned because I have to relearn where everything is, but it eventually wears off once I'm used to the changes.
My initial impressions:
"Hmmm... it seems like the category menus have been replaced by dropdown menus. It's not like I used many of them anyway."
"Okay, I've clicked my name to see my recently posted comments. Now, where's the link to see it in context? Oh, I guess I have to click that icon in the lower right corner. For some reason I was looking for something at the upper right of the comment box."
"Well, that worked. Now how do I click to the parent comment? Oh, wait, it's probably one of those new icons in the lower right corner. I'll just mouseover them to see what they do..."
::realization sets in::
"AAUGH! LESSWRONG IS USING MYSTERY MEAT NAVIGATION!!!"
So, what does everyone else think of the new redesign?