I haven't looked into this much. According to Massei, Umani Ronchi, a court-appointed expert, testified that a farinaceous meal takes 6-7 hours for gastric emptying, and additionally that it's possible some of the food passed into the duodenum but then, after death, slid into the small intestine. Massei also claims that even Vinci agreed with the range of 18:50 - 4:50 for time of death. Did the defence experts take into account the composition of the meal, or testify that sliding of the food after death is unlikely?
We're talking here not about the time it takes for the stomach to emtpy completely, but rather the time it takes for ingesta to begin passing into the duodenum ("T_lag"). (At death, there was 500mL of ingesta in the stomach -- consistent with the meal size -- and nothing in the duodenum.) According to this paper, the median value of T_lag is 81.5 minutes, and the 75th percentile is 102 minutes. (Furthermore, the median time for half the contents to empty ["T_1/2"] is 127 minutes, and the 75th percentile is 168.3 minutes.) The prosecution scenario of death during the 11:00 pm hour would require a T_lag of more than 240 minutes, possibly more than 300. My understanding is that this is basically unheard of, whatever the composition of the meal.
Ronchi claimed that the coroner, Lalli, had failed to seal the duodenum via ligature, as is apparently the standard procedure; this was the basis for his claim that food could have slipped into the small intestine. However, video of the autopsy revealed that Ronchi was wrong, and that Lalli had indeed properly sealed the duodenum. (Sollecito appeal, p. 165)
OK, what are the odds that a small dna trace left by "stabbing + cleaning" would test positive for blood, and what are the odds a small dna contamination to the knife would test positive for blood? (By the way, do you have a specific contamination hypothesis in mind?) In both cases, keep in mind only one "small zone" of the striation was tested for blood, and the rest of the striation was consumed in DNA analysis.
There were four samples on the blade, B,C,E, and G that were tested for blood; the results were all negative. These traces were all presumed to be blood by Stefanoni; it seems reasonable to suppose that if there had been blood on the knife, these would have been the most likely spots in which to have found it.
A positive blood test result would require more than DNA from (white) blood cells -- it would require hemoglobin. So it seems to me that the only way to get a positive blood test result from contamination would be to spill a blood sample on the knife. I estimate the probability of this having happened as being in the range of 0.001.
On the other hand, in the event that the knife had been used for stabbing, and that the victim's DNA remained on the knife, I would estimate a probability northward of 0.9 that at least one of the "presumed blood" traces would have tested positive for blood. (Cf. ChrisHalkides' comment below: "Two experts have publicly stated that the chances of cleaning a bloody knife to the point at which blood is no longer detected but DNA is detected, are small." This agrees with my intuition, and "no more than 0.1" seems a reasonable interpretation of "small".)
Sounds like she didn't document everything;
It's worse than that; what Conti and Vecchiotti describe is suggestive of deliberate misrepresentation if not outright fabrication of results. The "several hundred picograms" quantification result for Trace B appears to have been completely made up. She claimed in court that she had obtained this result using Real Time PCR, but this was not the case: records obtained by Conti and Vecchiotti show that another method ("Qubit Fluorometer") was used, and that the result obtained was "too low" -- the exact same as for Trace C. There was no justification for treating Trace B as a positive result and Trace C as a negative, and in particular no reason for subjecting Trace B to amplification.
The "amplification" (chemical copying of the sample in order to produce a large enough amount for analysis) was performed only once, despite the fact (admitted by Stefanoni) that it should be repeated in order to be considered reliable.
Can I get a source for Stefanoni's admission? Is this from the report?
Yes (p.61).
Stefanoni did not perform negative controls, which could have indicated the presence of contamination.
Is this also from the report? Have you translated this part yet?
This is on p. 79. This section of the report, on Stefanoni's knife results, is next in line to be translated (by my collaborator katy_did, while I'll be simultaneuously doing the clasp section).
The sample was analyzed in the same laboratory at the same time as numerous samples containing Meredith Kercher's DNA.
I gave a .05 chance that, if there was a cross-contamination, it would have been of Meredith's DNA. Are you giving a different probability?
Substantially different. Stefanoni is quoted as follows on p. 102 of the report:
"...the knife was analyzed...in the course of these 50 samples attributed to the victim, some were prior to the analysis of the knife, of course, and others subsequent, so in these 50 I don't know if the knife was, I don't know now, a fourth, a third of the way through this flux of analyses..."
This puts me at 0.5 or more. Also note that the number 50 itself gives a probability of 0.1 if we use your estimate of 500 total samples in the lab.
Let's talk about the dna some more once you guys have finished translating the relevant parts of the independent report, then, if your argument hinges on details of the independent report rather than just the conclusions.
We're talking here not about the time it takes for the stomach to emtpy completely, but rather the time it takes for ingesta to begin passing into the duodenum ("T_lag").
Sounds good. In your case, for one particular meal where the subjects had probably fasted beforehand, the lag is just under 2/3 of the half-time. If you acce...
Recently, on the main section of the site, Raw_Power posted an article suggesting that we find "worthy opponents" to help us avoid mistakes.
As you may recall, Rolf Nelson disagrees with me about Amanda Knox -- rather sharply. Of course, the same can be said of lots of other people (if not so much here on Less Wrong). But Rolf isn't your average "guilter". Indeed, considering that he speaks fluent Bayesian, is one of the Singularity Institute's largest donors, and is also (as I understand it) signed up for cryonics, it's hard to imagine an "opponent" more "worthy". The Amanda Knox case may not be in the same category of importance as many other issues where Rolf and I probably agree; but my opinion on it is very confident, and it's the opposite of his. If we're both aspiring rationalists, at least one of us is doing something wrong.
As it turns out, Rolf is interested in having a debate with me on the subject, to see if one of us can help to change the other's mind. I'm setting this post up as an experiment, to see if LW can serve as a suitable venue for such an exercise. I hope it can: Less Wrong is almost unique in the extent to which the social norms governing discussion reflect and coincide with the requirements of personal epistemic rationality. (For example: "Do not believe you do others a favor if you accept their arguments; the favor is to you.") But I don't think we've yet tried an organized one-on-one debate -- so we'll see how it goes. If it proves too unwieldy or inappropriate for some other reason, we can always move to another venue.
Although the primary purpose of this post is a one-on-one debate between Rolf Nelson and myself, this is a LW Discussion post like any other, and it goes without saying that others are welcome and encouraged to comment. Just be aware that we, the main protagonists, will try to keep our discussion focused on each other's arguments. (Also, since our subject is an issue where there is already a strong LW consensus, one would prefer to avoid a sort of "gangup effect" where lots of people "pounce" on the person taking the contrarian position.)
With that, here we go...