If you're promoting transhumanism, you're necessarily going to look weird to a lot of people. Is there anything in transhumanism that doesn't look weird? (This is a real question.)

I think that depends on how you express transhumanism. Take life extension, for example. If someone wants to have the option of indefinite physiological youth, are they running desperately from the inevitable spectre of death? Or are they people who love being alive and don't want such a good thing to end? Both of these descriptions are probably accurate for most transhumanists, but the latter will go over much better with a popular audience. Even stuff that sounds like it comes from a cyberpunk story, like surgically implanted computers, can be made more palatable if it's for something like minimally-invasive glucose monitoring.