I wonder if a lossy emulation might feel like/act like a human with a slightly altered brain chemistry. We have lots of examples of what it's like to have your neurons operating abnormally, due to emotion, tiredness, alcohol, other chemicals, etc etc. I'm not sure "uncanny valley" is the best term to capture that.
But I think those are examples of neurons operating normally, not abnormally. Even in the case of mind-influencing drugs, mostly the drugs just affect the brain on its own terms by altering various neurotransmitter levels. On the other hand, a low-level emulation glitch could distort the very rules by which information is processed in the brain.
Reading this article on requiring lots of processing power to emulate the snes accurately, made me think that we will likely have similar issues when emulating humans.
I'd imagine weird timing and chemical interactions being used by the brain as it is an adaptable system and might be able adapt to use them if they turn out to be helpful.
This suggested to me a few issues with no easy answers that I could see.