The most powerful argument I've had set against it is the ecological cost of refrigerating my ass for the next few centuries before (if!) I wake up again.
Is that a real argument? I'm not sure, but I thought I read somewhere that much commercial liquid nitrogen is generated as a by-product, so the ecological cost is pretty minimal.
(Of course, ecological cost is a dangerous route to travel if it isn't to be a full-time job. Leaving aside the obvious hypocrisy of anyone suggesting it while living a modern First World lifestyle, it's too easy to get wrong; for example, apparently a hybrid car is a massive net negative because it increases demand for heavy metal mining.)
That argument was made before I considered the economy of scale aspect, so I found it rather troubling at the time.
Over the past few months I've been doing a lot of reading about cryonics, and though I agree with the arguments of Eliezer Yudkowsky and Robin Hanson on the issue, I still feel uncomfortable about actually signing up. Upon reflection, my true rejection is my fear of the social cost of cryonics, i.e. being perceived as weird and completely incomprehensible by everyone around me. I've read the "Hostile Wife Phenomenon" article on Depressed Metabolism, the New York Times Magazine article on Robin Hanson's personal situation (as well as Robin's reply), and scores of comments on LessWrong, and it looks a lot of cryonicists do indeed experience the feeling that Eliezer describes in Lonely Dissent.
My concerns about the social cost of cryonics can be broken down into two categories:
Overall, though, I have very little information about what the social cost of cryonics really is beyond a few scattered anecdotes and secondhand descriptions of cryonicists' lives. Ultimately, I don't really know how many of my fears would actually be realized if I signed up. This makes it difficult to for me to make a decision, as I am very risk-averse and I feel reluctant to choose something that could potentially make the next six or seven decades of my life miserable. As a result, I have decided to engage in some data collection.
To do so, I would like to hear about your experiences. If you are currently signed up for cryonics, I would very much appreciate it if you took a minute or two to describe the effects that signing up has had on your relationships and your social life in general. If you are not signed up, your feedback on this topic is still welcome. Links to articles would be good, but discussion of personal experiences would be better.