EphemeralNight comments on [gooey request-for-help] I don't know what to do. - Less Wrong Discussion
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This does help immensely. After I finally figured out my sleep disorder, I was able to adjust for it, and suddenly both my mood and my health improved dramatically. (Of course, for me, that was a shift from suicidally depressed to melancholy and bored but it's still a huge improvement and just remembering the relative difference has a tendency to mildly cheer me further.)
I'd go on but my problems are different enough from chimera's that they're not relevant to this thread.