Derek Lowe has had several posts on that upcoming problem on his blog, http://pipeline.corante.com/ , over the past 6 months or so. And I strongly recommend his blog to anyone interested in pharmacology. He spends more time on the business and politics aspects than I really like, but also has good posts on scientific method and chemistry, his "Things I Won't Work With" series, http://pipeline.corante.com/archives/things_i_wont_work_with/ , is particularly entertaining.
EDIT: Links fixed. The markup on LW apparently attached the commas to the links.
LW uses Markdown syntax, so, there is another syntax for writing links:
[Markdown syntax](http://daringfireball.net/projects/markdown/syntax)
SIAI benefactor and VC Peter Thiel has an excellent article at National Review about the stagnating progress of science and technology, which he attributes to poorly-grounded political opposition, widespread scientific illiteracy, and overspecialized, insular scientific fields. He warns that this stagnation will undermine the growth that past policies have relied on.
Noteworthy excerpts (bold added by me):
In relation to concerns expressed here about evaluating scientific field soundness:
Grave indictors:
HT: MarginalRevolution