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gwern comments on Social status & testosterone - Less Wrong Discussion

28 Post author: gwern 20 October 2011 02:05PM

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Tags: motivation effect dopamine anxiety focus testosterone signalling

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Comment author: XFrequentist 20 October 2011 03:26:12PM *  5 points [-]

From your modafinil link:

Interestingly, there seem to be some groups for which modafinil does little or nothing, and this ineffectiveness may not be due to counterfeit product or poor self-monitoring, but genetics:

“…Two-time 100 mg modafinil potently improved vigor and well-being, and maintained baseline performance with respect to executive functioning and vigilant attention throughout sleep deprivation in Val/Val genotype subjects but was hardly effective in subjects with the Met/Met genotype.”

The genotype variation specifically refers to the Rs4680 SNP, which is one of the SNPs that services like 23andMe test for.

Crap, I'm Met/Met! Thanks for saving me some money though.

Comment author: gwern 20 October 2011 03:49:58PM 3 points [-]

You're welcome. You could get some and try anyway to see what happens - I've long wondered how reliable these SNP findings are.

Comment author: XFrequentist 20 October 2011 05:57:16PM *  3 points [-]

I'm curious too. I did my MSc thesis on pharmacogenomics (pdf), and am now generally skeptical of this sort of result. I'll have a closer look at the paper and make a decision. Any tips on procurement if the decision goes that way?

Comment author: knb 21 October 2011 04:52:11AM 1 point [-]

Google Adrafinil. It works very well for me. It is legal and unregulated in USA and some other places.

Comment author: gwern 20 October 2011 06:46:36PM 0 points [-]

Any tips on procurement if the decision goes that way?

Nothing that I haven't already written down or that a LWer shouldn't be able to figure out.

Comment author: MatthewBaker 20 August 2012 07:14:24PM 0 points [-]

mymodafinil.com

Comment author: gwern 20 August 2012 09:41:23PM 0 points [-]

I am well aware of that site, have received modafinil from it, and have even corresponded with the owner; ignorance of specific websites was not the point I was making.

Comment author: MatthewBaker 22 August 2012 05:27:08PM 0 points [-]

I just felt like the speed of my answer should still be of some benefit, and I wasn't aware that you had gained the knowledge of its existence in the month hence your previous comment.

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