I think that in a world with as many options as the transhumanists think of, some sort of a compulsory rumspringa for every culture/ sub culture might get instituted.

A rumspringa is a brief time where amish young men get to see the world. Similarly, some kind of a rule might be instituted where all young humans are given some time to explore other cultures. But in the case of disabilities, such therapy and re-baselining might take measures that are very expensive from today's perspective.