Question:
What are your thoughts on cryogenic preservation and the idea of medically treating aging?
His response:
A marvelous way to just convince people to give you money. Offer to freeze them for later. I'd have more confidence if we had previously managed to pull this off with other mammals. Until then I see it as a waste of money. I'd rather enjoy the money, and then be buried, offering my body back to the flora and fauna of which I have dined my whole life.
Fascinating. I've been waiting for a while for a well-educated neuroscientist to come here, as I think there are a lot of interesting questions that hinge on issues in neuroscience that are at least hard for me to answer (my only exposure to it is a semester-long class in undergrad). In particular, I'd be interested to know what level of resolution you think would be necessary to simulate a brain to actually get reasonable whole-brain emulations (for instance, is neuronal population level enough? Or do we need to look at individual neurons? Or even further, to look at local ion channel density on the membrane?)
Local ion channel density (i.e. active zones), plus the modification status of all those ion channels, plus the signalling status of all the presynaptic and postsynaptic modifiers (including NO and endocannabinoids).
You see, knowing the strength of all synapses for a particular neuron won't tell you how that neuron will react to inputs. You also need temporal resolution: when a signal hits the synapse #3489, what will be the exact state of that synapse? The state determines how and when the signal will be passed on. And when the potential from that input ... (read more)