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DavidAgain comments on Humans Shouldn't make Themselves Smarter? - Less Wrong Discussion
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Surely this depends on what you mean by 'improve the brain'. You might be able to make it better at things you consider important, by undermining things that the evolutionary environment deems important.
You could also trade off things that were more important in the ancestral environment than they are now. For example, social status (to which the neurotypical brain devotes much of its resources) is no longer the evolutionary advantage that it used to be.
You two realize you are just reinventing Bostrom's EOCs, right?
People, I wrote a thorough essay all about this! If I left something out, just tell me - you don't need to reinvent the wheel!
(This goes for half the comments on this page.)