Are you sure of this? I could point to many of our technological imperfections that caused great uneasiness in their day but are now considered normal and even natural. Further I could point to the eradication of diseases which were considered scourges of God and ultimately "part of the deal" or being human. Part of being a trans-humanist is a belief that contracts can and should be written as humanity becomes more technologically advanced.
Now changing a personality through manufactured means is considered an acceptable treatment of Autism, Bi-Polar Disorder, ADHD, Depression and many others. Now the drugging of conscious agents against their will is a moral problem, but to deny that as an option seems to be to be backward, rather than forward thinking. If I was offered a pill that would render my innate biases inert I would have little hesitation in taking it. As I simulate the decision now, the only objections I can think of are social biases wondering what people would think of a person with a black belt in rationality.
Now changing a personality through manufactured means is considered an acceptable treatment of Autism, Bi-Polar Disorder, ADHD, Depression and many others.
Actually, with regard to autism, at least, those are fighting words.
Singularitarians frequently lament the irrevocably dead and the lack of widespread application of cryonics. Many cryonocists feel that as many lives as possible should be (and in a more rational world, would be) cryopreserved. Eliezer Yudkowsky, in an update to the touching note on the death of his younger brother Yehuda, forcefully expressed this sentiment:
Ignoring the debate concerning the merits of cryopreservation itself and the feasibility of mass cryonics, I would like to question the assumption that every life is worth preserving for posterity.
Consider those who have demonstrated through their actions that they are best kept excluded from society at large. John Wayne Gacy and Jeffrey Dahmer would be prime examples. Many people write these villains off as evil and give their condition not a second thought. But it is quite possible that they actually suffer from some sort of mental illness and are thus not fully responsible for their crimes. In fact, there is evidence that the brains of serial killers are measurably different from those of normal people. Far enough in the future, it might be possible to "cure" them. However, they will still possess toxic memories and thoughts that would greatly distress them now that they are normal. To truly repair them, they would likely need to have many or all of their memories erased. At that point, with an amnesic brain and a cloned body, are they even really the same person, and if not, what was the point of cryopreserving them?
Forming a robust theory of mind and realizing that not everyone thinks or sees the world the same way you do is actually quite difficult. Consider the immense complexity of the world we live in and the staggering scope of thoughts that can possibly be thought as a result. If cryopreservation means first and foremost mind preservation, maybe there are some minds that just shouldn't be preserved. Maybe the future would be a better, happier place without certain thoughts, feelings and memories--and without the minds that harbor them.
Personally, I think the assumption of "better safe than sorry" is a good-enough justification for mass cryonics (or for cryonics generally), but I think that assumption, like any, should at least be questioned.