As with 3 we would expect a simulation to bottom out and not provide arbitrarily fine grained structure but in simulations precision issues also bring with them questions of stability. If the law's of physics turn out to be relatively unaffected by tiny computational errors that would push in the direction of simulation but if they are chaotic and quickly spiral out of control in response to these errors it would push against simulation.

We can expect the laws of physics to be relatively stable, simulation or no, due to anthropic reasoning. If we lived in a universe where the laws of physics were not stable (on a timescale short enough for us to notice), it would be very difficult for intelligent life to form.