If they are deleterious elements then instead of making cryonics harder, my bet would that it functions as another kind of "aging" that SENS would need to be able to fix in situ in order to achieve the grand vision of truly negligible senescence. My first thought in that direction is that you might need to create artificial work-alike "cells" to incrementally replace the ones whose DNA was becoming ever more infested with endogenous parasitic transposons... which sounds like a mature nanotechnological invention to me :-/